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Keynote Speakers ˇˇ

Keynote Speaker I

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Prof. Ho Chee Cheong

Universiti Tunku Abdul Rahman, Malaysia

Prof. HO Chee-Cheong received his MSc (1999) and PhD (1973) degrees from the University of Bristol, United Kingdom. He started work at the Rubber Research Institute Malaysia in 1973 before joining the University of Malaya in 1975 where he progressed to become a full professor in 1992 and Head of Department in 1994.  After his mandatory retirement in 1999, Dr. Ho was appointed R&D Director of a Glove manufacturing company, Thailand (1999 -2002) before returning to academic as the Foundation Dean and professor of a newly established university, AMIST University, Malaysia (2002-2006). He was appointed the first Vice-Chancellor of First City University College, a newly established university in Kuala Lumpur (2015-2017). He is an Adjunct Professor of Universiti Tunku Abdul Rahman,  Malaysia since 2008.

Dr. Ho specializes in latex chemistry and technology, particularly in the use of green technologies for latex processing and glove dipping. He was awarded the DSc degree by University of Bristol in 1998 for his contribution to understanding the colloidal and surface properties of natural rubber latex and elucidating its film formation mechanism. He received the Science and Technology Award by the Malaysian Toray Science Foundation in 1997. He was later honoured with the National Science Award for research in 1999 in recognition of his lifelong research work on colloidal systems of values to the Malaysian economy (natural rubber latex, palm oil mill effluent, industrial applications of palm oil emulsion and tin tailings slurry).  Dr. Ho is a Past President of the Malaysian Institute of Chemistry and a Senior Fellow of the Academy of Sciences Malaysia. He was elected a Fellow of the ASEAN Academy of Engineering and Technology in 2010 and the Royal Society of Chemistry, UK in 1990.

Speech Title: Innovations in barrier device for infection control

Abstract: Infection control in healthcare and hospital facilities is of utmost importance in present day context of frequent outbreaks of infectious diseases in a highly mobile and interconnected world. Medical glove is the frontline protection against cross-infection by pathogens among healthcare worker and patients. The wearing of medical gloves by healthcare workers has been made mandatory in the developed countries since the 1980s.

William Haldsted was credited as the first to introduce the use of natural rubber (NR) gloves during surgery in 1889 -1890 at Johns Hopkins Hospital, Baltimore USA [1].  It was mentioned that surgeons at the hospital noticed the number of infection significantly decreased when NR gloves were used during surgery [2].  Those gloves were thick and most probably hand-dipped. Ansell was recorded to be the first to design and built an automatic dipping machine that produced 300 dozen pairs of gloves in eight hours in 1945 [3]. The company introduced disposable surgical gloves in 1964 and went on to become the largest producer of latex glove for house and medical use in those days. The use of medical gloves as a barrier device against infection became mandatory after the emergence of AIDS/HIV pandemic in the 1980s. This had spurred strong demand for medical gloves for healthcare workers. In the ensuing years each outbreak of highly infectious diseases such as the avian flu, SARS and MERS was accompanied by a corresponding spike in demand for medical gloves. The strong demand for medical gloves has driven the glove manufacturing industry to continuously improve its productivity and quality. Many innovative measures have since been incorporated into the dipping process.

 

Keynote Speaker II

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Prof. Hiroyuki Nakamura
Tokyo Institute of Technology, Japan

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Hiroyuki Nakamura was received his PhD from Tohoku University under the supervision of Professor Yoshinori Yamamoto in 1996. He became an assistant professor at Kyushu University (1995-1997) and at Tohoku University (1997-2002). He worked as a visiting assistant professor at University of Pittsburgh with Professor D. Curran (2000-2001). In 2002, he was appointed as an associate professor at Gakushuin University and promoted as a professor in 2006. In 2013, he was appointed as a professor at Tokyo Institute of Technology. He received the Chemical Society of Japan Award for Young Chemists in 1999 and the Incentive Award of the Japanese Society for Molecular Target Therapy of Cancer in 2007. He became president of the Japanese Society of Neutron Capture Therapy in 2015. His research interests include synthetic methodology, medicinal chemistry, chemical biology, photodynamic therapy, and neutron capture therapy.

Speech Title: Boron Neutron Capture Therapy: Current Status and Future Aspect

Abstract: Boron neutron capture therapy (BNCT) has been attracting growing interest as one of the minimally invasive cancer therapies. BNCT uses the nuclear reaction between low-energy thermal neutron (0.025 eV) and boron-10 (10B), and the generated ¦Á-particle and lithium nuclei are high linear energy transfer (LET) particles (2.4 MeV) that are sufficiently powerful to kill cells. Therefore, selective delivery of 10B atoms to tumor is essential for effective BNCT. Mercaptoundecahydrododecaborate (Na2[B12H11SH]) and L-p-boronophenylalanine (L-BPA) have been used in BNCT for many years. L-BPA, in particular, has been widely used for the treatment of not only melanoma but also brain tumor and head and neck cancer because it can be taken up selectively by tumor cells through an amino acid transporter. The accelerator-based BNCT is now undergoing phase II clinical study for the treatment of brain tumor and head and neck cancer patients in Japan. However, development of new boron carriers is still strong requirements for patients who are not able to be treated with L-BPA.

Serum albumin, a major plasma protein constituent, is composed approximately 55% of the human plasma protein. Albumin accumulates in malignant and inflamed tissues due to enhanced permeability and retention (EPR) effect. Furthermore, it has been observed that tumor is the major site of serum albumin catabolism, thus serum albumin has been extensively investigated as a versatile carrier for therapeutic and diagnostic agents, including diabetes, cancer, rheumatoid arthritis and infectious diseases. For example, Abraxane®, an albumin-paclitaxel nanoparticle, is the most advanced drug delivery product first approved by FDA in 2005 for the treatment of metastatic breast cancer. We developed maleimide-functionalized closo-dodecaborate (MID) for conjugating bovine serum albumin (BSA) as new boron delivery system. The highly boronated BSA showed high and selective accumulation in tumor. Significant tumor growth inhibition was observed in colon 26 tumor-bearing mice subjected to thermal neutron irradiation.

Keynote Speaker III

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Shen-Ming Chen

National Taipei University of Technology, Taiwan

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Prof. Shen-Ming Chen (h-index > 60) received his PhD degrees in chemistry from National Taiwan University, Taipei, Taiwan. He was a visiting postdoctoral fellow with the Institute of Inorganic Chemistry, Friedrich-Alexander University Erlangen-Nuremberg, Germany in 1997. He joined Department of Chemical Engineering, National Taipei Institute of Technology, Taipei, Taiwan in 1985. He had been an associate professor of Department of Chemical Engineering, National Taipei Institute of Technology, Taipei, Taiwan from 1991 to 1997. Since August 1997, he has been a full professor of Department of Chemical Engineering and Biotechnology, National Taipei University of Technology. He has been the Dean (Curator) of library, National Taipei University of Technology, Taiwan from 2000 to 2006 and the Director of Extracurricular Activity, office of student affairs, National Taipei University of Technology, Taiwan from 1995 to 2000.
Prof. Shen-Ming Chen has published over 500 research and review papers in internationalSCI journals. Some of their papers have been selected as the most cited papers in theJournal of Electroanalytical Chemistry and Biosensor & Bioelectronics. He received threetimes Distinguish Professor awards. He also received three times Outstanding Research Award from National Taipei University of Technology, Taiwan. He have edited or attended two books for NOVA publications titled ˇ°Nanostructured Materials for Electrochemical Biosensorsˇ± and ˇ°Biosensors: Properties, Materials and Applicationsˇ± and contributed four book chapters.

Speech Title: Design and synthesis of nanostructured binary metal oxides for electrocatalysis, electroanalysis and biosensors

Abstract: Development of nanostructured materials with superior morphology by simple methodology has incessantly received a significant scientific interest due to their unique physical and chemical properties for the applications in electrochemical sensors and biosensors. Binary metal oxides, particularly, metal molybdates and tungstates possess enormous attentions due to their high electrical conductivity, excellent structural stability and reproducibility compared to single one. In this regard, we fabricated different metal molybdates and tungstates with well-defined morphology and utilized as chemical sensors and biosensors in real environment and biological fluids. For occasion, two-dimensional plate-like tin molybdate was fabricated via simple co-precipitation route and employed as an electrochemical for the detection of neurotoxicity drug clioquinol. Highly sensitive and selective electrochemical sensor for the identification of postharvest scald inhibitor diphenylamine was developed using seed-like strontium molybdate modified electrode. A flower-like neodymium molybdate was prepared and studied towards the selective electrochemical sensor for the antibiotic drug nitrofurantoin. The CoWO4 nanospheres was prepared by low temperature chemical synthesis method and evaluated towards the sensitive detection of glucose biosensor. A novel nickel tungstate was synthesized using simple hydrothermal treatment without using any surfactant or templates and investigated for its electrochemical properties for the detection of glucose biosensor. Well-crystalline 2D cerium tungstate nanosheets were prepared by a simple wet chemical approach and used as an excellent electron mediator for the fabrication of nitrite sensor. A novel ruthenium nanoparticles decorated tungsten oxide based sensor was developed and its catalytic behavior was demonstrated towards the oxidation of hydrazine. The aforementioned nanomaterials were furnished a good electrocatalytic activity with appreciable stability towards the chemical sensors and biosensors when compared with the previously reported sensors. The analytical parameters such as linear response range, sensitivity, limit of detection and reproducibility of the devices also been carried out and compared with the current state of the art.

 

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